Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Shou-Lin Wang, Zhan Zhang, Shushu Li, Li Wang, Xichen Wang and Chao Wang
Scientific Tracks Abstracts: J Clin Toxicol
The study aims to illustrate the association of 2, 2’4, 4’-tetrabromodiphenyl ether (BDE47) with diabetes in a two-stage casecontrol
study and animal experiment. All the participants received a questionnaire, health examination, and the detection of 7
PBDE congeners in serum. Then, male rats were exposed to BDE47 for 8 weeks to explore its effects on glucose homeostasis, and
potential mechanisms using high-throughput genomic analysis. Detection rate of serum ΣPBDEs in cases was significantly higher
than controls, which presented a higher risk in the 3rd tertile of ΣPBDEs, particularly in Study II (OR=2.32, ptrend=0.031). Among the
7 congeners, BDE47 showed significant high detection rate and concentration in cases in both two studies and their combination.
Every tertile of BDE47 significantly increased the risk of diabetes, particularly in Study II (ptrend=0.006) and the combined study
(ptrend=0.002). Animal experiments confirmed that BDE47 treatments induced hyperglycemia in male rats. Furthermore, gene
microarray analysis showed that type 1 diabetes (T1D) pathways and three gene ontology (GO) terms involved in glucose transport
were enriched. The study first demonstrated that environmental exposure to BDE47 might increase the risk of diabetes through
activation of T1D pathways and upregulation of genes involved in glucose transport.
Shou-Lin Wang has completed his PhD in 2006 from Nanjing Medical University (NMU), China, and Postdoctoral studies from Rutgers University School of Public Health.
He is the Head and Professor of Department of Occupational Medicine and Environmental Health, NMU. He has published more than 100 papers in reputed journals and
got several scientific awards in China.