Mariana Robalo Cordeiro, Barbara Laranjeiro, Fernanda Geraldes, Margarida Figueiredo-Dias
Gynecology Department, Universitary Hospital Center of Coimbra, Portugal Universitary Clinic of Gynecology, Faculty of Medicine, University of Coimbra, Portugal
Scientific Tracks Abstracts: Gynecol Obstet (Sunnyvale)
Endometriosis has been considered an estrogen-dependent chronic inflammatory disease affecting women of reproductive age. Recent evidence suggests a shift in this paradigm, considering the possible occurrence of de novo endometriosis diagnosis in postmenopausal women. The present study aims to help understanding the pathophysiology and clinical management of such enigmatic entity after menopause. A total of 208 patients with histologic proven endometriosis were included in this cross-sectional study. Pearson linear correlations with collected data were performed using IBM® Cloud Pack ® For Data and further descriptive statistics was made using IBM® SPSS® v26. The study sample included 6 cases of postmenopausal de novo endometriosis, which represents a 2.88% prevalence. Patients mean age at diagnosis was 56 years [50-79] . Only 16.3% (n = 1) was using menopausal hormone therapy (MHT) and, interestingly, a strong positive correlation was observed between MHT and pelvic pain symptoms (r = 1). Ovarian localization was observed in 83.3% of the sample. Nevertheless, no positive correlation was observed between CA-125 serum values and postmenopausal endometriosis (r = -0.15) comparing to premenopausal women (r = 0.39). The results of this study are in accordance to previous evidence on the subject, highlighting that endometriosis is a rare and poorly understood condition in postmenopausal women. Management of endometriosis in symptomatic menopausal women and risk of malignant transformation remain uncertain. The growing awareness on this topic makes the need for high-quality studies a certainty.
Mariana Robalo Cordeiro has completed her Master Degree in Medicine at the age of 24 years from Faculty of Medicine of the University of Coimbra and has a Post-graduation in Artificial Intelligence in Healthcare from Massachusetts Institute of Technology. She is a Gynecology and Obstetrics Resident at Universitary Hospital Center of Coimbra