Journal of Chemical Engineering & Process Technology
Open Access

Elucidating proton-mediated conformational changes in the acid-sensing ion channel 1a through molecular dynamics simulation

JOINT EVENT ON 5^th International Conference on Bioplastics and 6^th World Congress on Biopolymers

September 07-09, 2017 | Paris, France

Xu-ri Huang, Lu Liu, Xian-yang Zeng and Xi Zhao

Jilin University, China

Posters & Accepted Abstracts: J Chem Eng Process Technol

Abstract :

Acid-sensing ion channel 1a(ASIC1a) as proton-activated receptor cation channel, contributes to sensory transduction, depression and fear-related behaviors throughout nervous system. So far, how proton mediates the channel gating process still remains elusive. Here we report that the ion pore changes at different PH values through molecular dynamics (MD) simulations. The path of long-range conformational changes from the extracellular domain to the transmembrane domain was determined; further, the correlation network analysis reveals how the interactions between subunits influence the channel gating changes. �²1, �²2, �²10, �±6, �±7, �²11 and �²12 are the crucial regions by forming a passageway to regulate the ion pore changes. Our results reveal the process that the extracellular domain remotely regulates the pore changes.

Biography :

Xu-ri Huang has completed his PhD in 1991 from Jilin University. Now He is a professor of Institute of Theoretical Chemistry, Jilin University. His research focuses on theoretical chemistry, such as catalysis reaction mechanism and biomolecular simulation. He has published more than 150 papers in reputed journals.