Effect of sterilization on the physical stability of Brimonidine- | 6231
Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631

+44 1478 350008

Effect of sterilization on the physical stability of Brimonidine-loaded solid lipid Nanoparticles and Nanostructured lipid carriers

Joint International Conference and Expo on Industrial Pharmacy & 5th Global Pharmacovigilance Summit

April 28-29, 2016 Dubai, UAE

Noha S El-Salamouni

Pharos University in Alexandria, Egypt

Posters & Accepted Abstracts: J Develop Drugs

Abstract :

Nanoparticulate delivery systems have recently been under consideration for topical ophthalmic drug delivery. Brimonidine baseloaded solid lipid nanoparticles and nanostructured lipid carrier formulations were prepared using glyceryl monostearate as solid lipid and were evaluated for their physical stability following sterilization by autoclaving at 121�?°C for 15 minutes. The objective of this work was to evaluate the effect of autoclaving on the physical appearance, particle size, polydispersity index, zeta potential, entrapment efficiency and particle morphology of the prepared formulations, compared to non -autoclaved ones. Results showed that, autoclaving at 121�?°C for 15 minutes allowed the production of physically stable formulations in nanometric range, below 500 nm suitable for ophthalmic application. Moreover, autoclaved samples appeared to be superior to non -autoclaved ones, due to their increased zeta potential values, indicating a better physical stability. As well as, increased amount of brimonidine base entrapped in the tested formulations.

Biography :