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Maha A El-Gayyar
Mansura University, Egypt
Posters-Accepted Abstracts: Endocrinol Metab Syndr
Insulin resistance (IR) and associated hyperinsulinemia (HI) are the main pathogenic factors of acanthosis nigricans (AN) associated with obesity and or polycystic ovarian syndrome (PCOS). Metformin, as an insulin sensitizing drug, may offer a selective therapeutic approach for AN. We have evaluated the correlations of AN severity grade to body mass index (BMI), waist-to-hip ratio (WHR), IR, serum levels of insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein (IGFBP-1) in obese females having AN with or without PCOS compared to obese females without AN and determine the efficacy of metformin in the treatment of AN. We concluded that PCOS is more prevalent among obese females with AN. So, obesity together with AN could be early predictors of PCOS in such patients. Also metformin therapy not only clinically improved AN lesions but also restores normal levels of insulin and decreases the pool of free-bioactive IGF-1 by increasing the levels of circulating IGFBP-1in AN patients with and without PCOS. Therefore, hyperinsulinemic women with AN+PCOS may benefit from a trial of metformin for improvement of skin lesions, signs and symptoms of PCOS and underlying HI.