Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Sane Rohit, Patil Atul, Aklujkar Abhijeet and Mandole Rahul
India
Posters & Accepted Abstracts: J Clin Exp Cardiolog
Objectives: The present study was designed to evaluate effect of heart failure reversal therapy (HFRT) using herbal procedure (Panchakarma) and allied therapies, as add-on to standard treatment (SCT) in chronic heart failure (CHF) patients. Methods: This open-label, randomized study conducted in CHF patients (aged 25-65 years, ejection fraction between 30%- 65% [inclusive]), had three phases: 1-week screening, 6-week treatment (randomized [1:1 ratio] to HFRT+SCT or SCT-alone) and follow-up (12-week). Twice weekly HFRT (60-75 minutes) consisting of snehana (external oleation), swedana (passive heat therapy), hrudaydhara (concoction dripping treatment) and basti (enema) was administered. Primary endpoints included evaluation of change in metabolic equivalents of task (MET) and peak oxygen uptake (VO2peak) from baseline, at end of 6-week treatment and follow-up at week-18 (non-parametric rank ANCOVA analysis). Safety was assessed. Results: Total 70 CHF patients (mean [SD] age: 53.0 [8.6], 80% men) were enrolled in the study; 35 randomized to each treatment arm. All patients completed treatment phase. Add-on HFRT caused a significant increase in METs (least square mean difference [LSMD], 6-week: 1.536, p=0.0002; 18-week: ��?1.254, p=0.0089) and VO2peak (LSMD, 6-week: -5.52, p= 0.0002; 18-week: ��?4.517, p=0.0089) as compared with SCT alone. Results were suggestive of improved functional capacity in patients receiving add-on HFRT. Total 7 treatment-emergent adverse events were reported in HFRT arm; all mild severity. Conclusion: Findings of the present study highlight therapeutic efficacy of add-on HFRT as compared with SCT-alone in CHF patients. The non-invasive HFRT showed no safety concerns.
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