Journal of Clinical Toxicology
Open Access

Effect of antiretroviral therapy on the risk factors for cardiovascular and renal diseases amongst HIV-infected patients in a Nigerian university teaching hospital

6^th Global Summit on Toxicology & Applied Pharmacology

October 17-19, 2016 Houston, USA

Usman Sikiru Olatunji

University of Lagos, Nigeria

Posters & Accepted Abstracts: J Clinic Toxicol

Abstract :

Background: Antiretroviral therapy (ART) has been reported to cause insulin resistance, low HDL and other abnormalities that may increase the risk for the development of cardiovascular and renal diseases. Objectives: This study was aimed at evaluating the effects of different antiretroviral regimens on the risk factors for the development of cardiovascular and renal diseases in HIV-infected patients. Method: The database of 625 HIV-infected patients, on ART for a minimum of five years, was analyzed retrospectively to determine the association between the drugs and cardiovascular or renal diseases outcomes. Results: Antiretroviral therapy regimens based on lamivudine, stavudine, nevirapine or tenofovir were significantly associated with elevated blood pressure, insulin resistance and chronic kidney disease (p<0.05). In addition, age (p=0.04, OR=1.019) and sex (p=0.01, OR=0.512) were significant risk factors for hypertension while age alone was a significant risk factor for diabetes (p=0.03, OR=0.928) Conclusion: Antiretroviral therapy regimens were significantly associated with the development of cardiovascular and renal diseases with lamivudine, stavudine, tenofovir and nevirapine-based regimens showing the highest risk.

Biography :

Email: sikiruusman2004@yahoo.com