EDesign, synthesis and characterization of glycolipids and glycoc | 4049
Journal of Glycobiology

Journal of Glycobiology
Open Access

ISSN: 2168-958X

EDesign, synthesis and characterization of glycolipids and glycoclusters

Glycobiology World Congress

August 10-12, 2015 Philadelphia, USA

Guijun Wang

Scientific Tracks Abstracts: J Glycobiol

Abstract :

Glycolipids and glycoclusters that are able to form self-assembled supramolecular structures are interesting compounds with
potential applications as new materials for biomedical research. Our group has a long interest in the design, synthesis and
study of various monosaccharide derivatives and we have discovered several new classes of glycolipids based low molecular weight
gelators (LMWGs). These compounds form unique soft materials such as organogels or hydrogels that may be useful in biomedical
research. They can be used as advanced functional materials for controlled release drug delivery and enzyme immobilization. Using
naproxen as a model, we have shown that acid sensitive glucosamine derivatives are effective compounds for controlled release
of naproxen from the gel matrix. By incorporating photosensitive functional groups, we have also synthesized and characterized
polymerizable diacetylene containing organogels. The resulting polydiacetylenes gels are useful as stimuli-responsive soft materials.
Besides these systems, several branched molecules with sugar moieties at the periphery have also been designed and synthesized.
These compounds have accurate molecular weight and can form interesting molecular assemblies. The dendritic glycolipids have
shown enhanced self-assembling tendencies which mimic the multi-valency effect. In this presentation, our recent studies on
glycolipids that can form supramolecular gels and self-assembling glycoconjugates will be discussed.

Biography :

Guijun Wang has completed her PhD in 1999 from Michigan State University and Postdoctoral research at Yale University in 2002. She started her independent
career as an Assistant Professor at the University of New Orleans in 2002. In 2012, she relocated to Old Dominion University (ODU). Currently she is a Professor
of Chemistry and Biochemistry at ODU. Her research interests include synthetic methodology development; asymmetric synthesis and the synthesis and study of
carbohydrate based self-assembling systems. She has co-authored 50 peer reviewed papers and is the Co-Inventor on 20 international and US patents.