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Echocardiographic correlates of pulmonary hypertension in adult patients with atrial septal defect
Clinical & Experimental Cardiology

Clinical & Experimental Cardiology
Open Access

ISSN: 2155-9880

Echocardiographic correlates of pulmonary hypertension in adult patients with atrial septal defect


18th Annual Cardiologists Conference

June 19-21, 2017 Paris, France

Nilda Espinola-Zavaleta, Jorge Cossio-Aranda, Karina Del Valle Zamora and Navin C Nanda

National Institute of Cardiology Ignacio Chavez, Mexico
University of Alabama, USA

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

Aim: Aim of this study is to identify echocardiographic factors that correlate with pulmonary hypertension (PH) in adults with ostium secundum atrial septal defect (ASD). Methods: From November 2009 to November 2013, 92 adults with ASD were studied. All had clinical history and transthoracic echocardiogram. Results: 39% of patients had severe PH defined as systolic pulmonary artery pressure (sPAP) of 70 mm Hg or more. The size of ASD (31.84?±8.21 mm) and a right sided tricuspid inflow E wave to tissue Doppler e?´wave ratio >6.2 correlated with severe PH with AUC of 0.704 (CI 95%=0.59 to 0.818, p<0.001) and 0.65 (CI 95%=0.531 to 0.773, p<0.014), respectively. Multivariate logistic regression showed that sPAP>70 mm Hg was the variable that most precisely correlated with right ventricular (RV) dysfunction as evidenced by TAPSE <17 mm and RV fractional shortening area (RVFSA) <35%. Left ventricular (LV) diastolic function was also significantly reduced in the group with severe PH mitral inflow E/A ratio of 0.73?±0.23 vs. 1.13?±0.42 in the group without severe PH (sPAP<70 mm Hg, (p=0.001). The pulmonary (Qp) to systemic (Qs) cardiac output ratio (3.09?±1.12) and right sided tissue Doppler S<9.5 cm/sec most accurately predicted a Tei index>0.55. Conclusions: Larger size of ASD using the QP/QS ratio and increased right-sided tricuspid E/eâ?? ratio correlated with severe PH with a sPAP of 70 mm Hg or more. Patients with severe PH had more severe RV dysfunction as evaluated by TAPSE and RVFSA in comparison to those with PH <70 mm Hg. LV diastolic function was also reduced in the severe PH group.

Biography :

Email: [email protected]

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