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Lomas Tomar, Charu Tyagi, Yahya E Choonara and Viness Pillay
University of the Witwatersrand, South Africa
Posters-Accepted Abstracts: J Pharma Care Health Sys
Stimuli-responsive polymeric biomaterials are under extensive research for their use as a carrier for oral drug delivery systems. The aim of this study was to synthesise and characterise a dual-sensitive copolymeric biomaterial responsive to temperature and pH as both of these stimuli are important physiological parameters. Copolymer of poly (NIPAM)-co-acrylic-co-methacrylic acid were synthesized by using free radical polymerisation method using different concentrations of fed monomers. Synthesized copolymers were characterized by FTIR, DSC, texture analysis and Karl-Fischer titration. These systems were further evaluated for their swelling efficacy and in vitro drug release under the influence of different temperature and pH environment. FTIR spectrum confirmed the synthesis of the copolymer and thermal analysis using DSC proved that the copolymer was stable at high temperature. Results of the swelling studies showed an increased swelling at 37 �?°C and pH 7.4. The insulin release studies at various temperature and pH over 180 minutes recorded highest release at 37 �?°C: up to 78% at pH 7.4 and up to 30% at pH 1.2, while a comparatively lower release was observed at 4�?°C: up to 28% at pH 7.4 and up to 17% at pH 1.2. The properties of the synthesized copolymer and their in vitro insulin release behaviour prove its potential as a material for oral delivery of therapeutic peptides.