Clinical & Experimental Cardiology
Open Access

Does N-terminal pro-brain natriuretic peptide level predict prognosis of acute Pulmonary Embolism?

16^th World Cardiology Congress

December 08-10, 2016 Dubai, UAE

Abdelaziz Gomaa and Hanan Radwan

Zagazig University, Egypt

Scientific Tracks Abstracts: J Clin Exp Cardiolog

Abstract :

Background: Patients with acute Pulmonary Embolism (PE) have a high risk of death. N-terminal pro-brain natriuretic peptide (NT-pro BNP) has emerged as a biomarker for risk assessment in acute PE. Aim: We aimed to detect in hospital prognostic value NT- pro BNP in patients with acute PE. Methods: 64 patients with acute PE were studied. All patients were subjected to ECG, laboratory tests (D-dimer, troponin I, NT-pro BNP), Doppler ultrasound for the venous system of lower limbs, transthoracic echocardiography and 64 multi-slices CT pulmonary angiography. Results: Patients were divided into two groups: group I (22) patients with normal NTpro BNP (<300 pg/ml), and group II (42) patients with elevated NT-pro BNP. Group II had higher incidence of heart failure (28.6% vs. 4.6% P=0.025), impaired kidney function (creatinine 1.7�?±0.6 vs. 1.1�?±0.2, P=0.018) and cardiogenic shock (26.2% vs. 0% P=0.014) but lower incidence of chest pain (21.4% vs. 45.5% P=0.04) and lower LV ejection fraction (51.3%�?±16.9% vs. 67.3%�?±12.8% P=0.043) compared to group I. Group II had higher treatment with thrombolytic therapy (35.7% vs. 9.1%, P= 0.021) and positive inotropic (35.71% vs. 4.55%, P=0.006), higher need for mechanical ventilation (26.2% vs. 4.55%, P=0.04), longer hospital stay (19.5�?±10.3 vs. 5.3�?±4.5, p=0.001) and higher mortality (19.05% vs. 0.0% P=0.042) than group I. Conclusion: Elevated NT-pro BNP levels in patients with PE are associated with worse short term prognosis in terms of higher morbidity and mortality and it could be used as a valuable prognostic parameter and good indicator for the need of more aggressive therapy.
Recent publications:
1. S. Z. Glodhabber, â�?�?Pulmonary Embolism. Braunwaldâ�?�?s Heart Disease: A Textbook of Cardiovascular Medicine,â�? 9th Edition, Saunders, 2012.
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4. R. Cavallazzi, A. Nair, T. Vasu and P. E. Marik, â�?�?Natriuretic Peptides in Acute Pulmonary Embolism: A Systematic Review Published Online,â�? Vol. 34, No. 12, 2008, pp. 2147-2156
5. N. Vuilleumier, M. Righini, A. Perrier, A. Rosset, N. Turck, J. C. Sanchez, H. Bounameaux, G. Le Gal, N. Mensi and D. Hochstrasser, â�?�?Correlation between Cardiac Biomarkers and Right Ventricular Enlargement on Chest CT in Non Massive Pulmonary Embolism,â�? Thombo Re-search, Vol. 121, No. 5, 2008, pp. 617-624. doi:10.1016/j.thromres.2007.07.003

Biography :

Abdelaziz Gomaa is a Consultant Interventional Cardiologist at Dallah Hospital Riyadh, KSA and a Lecturer of Cardiology at Zagazig University, Egypt. He is pursuing certified level II training in Cardiac CT (Harefield-London Cardiac CT course) in addition to interventional cardiology practice. His work in Clinical Cardiology gave him good overview of different cardiology emergencies and urgencies.

Email: a_gomaa2000@yahoo.com