Kiroj Rajbanshi, Rajiv Bajracharya, Ashwinee Shrestha and Panna Thapa
Kathmandu University, Nepal
Posters & Accepted Abstracts: Drug Des
Present study was carried out to enhace the dissolution rate of poorly water soluble drug Aceclofenac (BCS-II), by solid dispersion technique using different carrier and super disintegrant by Kneading method. Screening of carrier and super disintegrant having better dissolution effect was performed by Plackett-Burman design. Carrier that were selected for the study include Hydroxypropyl Beta Cyclodextrin (HPBCD), premix of Lactose and Maize Starch and Mannitol. Similarly, as superdisintegrant, Sodium Starch Glycolate (SSG), Croscarmellose and Crospovidone were selected. Among the carriers and superdisintegrants, Mannitol and Crospovidone showed best effect on dissolution, respectively. For optimizaton of concentration of Mannitol and Crospovidone in solid dispersion, Central Composite Design (CCD) was applied for two factor at two level which gave 13 formulations. Tablets were prepared and evaluated for physiochemical properties. Reponse surface plot and contour plot were drawn and an optimum formulation was selected, which contained 114.14 mg of Mannitol and 10.5 mg of Crospovidone. The in vitro dissolution studies of optimized formulation CCDF8 and the marketed product were carried out in USP Type II apparatus at different time interval of 5, 15, 30 and 45 minute at 50 rpm in phosphate buffer, pH 7.5 (0.33 M mixed). Solid dispersion was evaluated by FTIR. It showed that the drug was stable in solid dispersion. Hence, solid dispersion technique can be sucessfully used for the improvement of the dissolution profile of Aceclofenac.