Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Aysu Yurdasiper Erdem
Ege University, Turkey
Scientific Tracks Abstracts: J Develop Drugs
Statement of the Problem: Asthma is a heterogenic disease occurring in both adults and children worldwide. Over the past decade, orally inhaled fixed-dose agents have emerged as an important therapeutic class for treatment of asthma. Current guidelines recommend inhaled corticosteroids as the basis of initial controller treatment. Several factors such as correct use of inhalers and adherence to the treatment affect the outcome of the disease and have been described to be major barriers for successful treatment. Objective: The objective of this study was to develop Fluticasone Propionate (FP) Dry Powder Inhalers (DPI) containing different carriers using spray drying technique and characterize the powder in terms of aerosolization, flow properties in order to determine which formulations could be the most suitable for pulmonary delivery. Materials & Methods: Trehalose, Mannitol and Leucine were used as carriers. The mixtures were spray-dried with constant stirring using a Buchi Nanospray Dryer B-90. A simple, rapid, accurate and sensitive method was developed for quantitative analysis of FP using High Performance Liquid Chromatography (HPLC) with UV detection. The chromatography parameters were Thermo Scientific Hypersil ODS C18, (5 �?¼m, 4,6x250 mm). The isocratic mobile phase was acetonitrile:water (65:35; v/v) at a flow rate of at 1.0 mL.min-1. The determinations were performed using UV-V is detector set at 238 nm. The in vitro aerosolization performance was investigated using Next Generation Impactor (Copley). Results & Discussion: SEM images of DPI formulations showed almost spherical structures with particle size 1-5 �?µm. Also the sizes of the particles were determined by laser diffraction with a dry sampling system (Mastersizer 3000 Malvern instruments). Process yield values were higher than 86.�?±2.8% and encapsulation efficiency values were above 81.�?±3.2%. The optimized formulation developed in this study exhibited good in vitro aerosolization properties. The Carrâ�?�?s Index is higher for the formulation with trehalose.
Aysu Yurdasiper Erdem has obtained her BSc and MSc Degrees in Faculty of Pharmacy from Ege University respectively, followed by a PhD Degree from the same department. She has studied as a PhD student with TUBITAK Scholarship in Cardiff University, Welsh School of Pharmacy, Cardiff, UK. Her work is focused on dry powder inhalers, dermal delivery (topical, transdermal drug systems), controlled release formulations (nanoparticles, microparticles) for drug delivery. She is Editor in Chief for American Journal of Drug Delivery and Therapeutics and also Editorial Board Member of several international journals. She has filed a national patent on dry powder inhaler formulation. She has been working as a Researcher in the Department of Pharmaceutical Technology, Ege University. Her current research interests focus on development of novel nano-micro medicine including polymers and in vitro-in vivo evaluation for treatment of respiratory diseases.
Email:aysuyurdasiper@hotmail.com