Drug Designing: Open Access
Open Access
ISSN: 2169-0138
+44 1223 790975
ISSN: 2169-0138
+44 1223 790975
Shashank Tummala and M N Satish Kumar
Posters-Accepted Abstracts: Drug Des
5-Fluorouracil is used in the treatment of colorectal cancer along with oxaliplatin as first line treatment, but it is still having lack of
site specificity and poor therapeutic effect. Apart from that it exhibits toxic effects to healthy cells and decrease the drug availability
at colon region. These limitations were overcome by formulating them as enteric- coated chitosan polymeric nanoparticles as drug
can be delivered directly to large bowel. The main reason for opting for enteric coating is due to its protection of drug at gastric pH. So
the main objective was to prepare polymeric nanoparticles using chitosan with different ratios of polymer (1:1, 1:2, 1:3, 1:4) by solvent
evaporation emulsification method. It was then characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD),
entrapment efficiency and particle size and further subjected to enteric coating. Dialysis bag technique was selected to determine
drug in vitro release using various simulated fluids with pH (1.2, 4.5, 7.5, 7.0) to mimic the GIT tract. 5-FU nanoparticles with drug:
polymer ratio of 1:2 and 1:3 has shown better particle size (149±1.28 nm and 138±1.01 nm respectively), entrapment efficiency
(48.12±0.08% and 69.18±1.89 respectively). Comparative approach with non-enteric coated tablets shows a better drug release for
5-FU E1 after 4 h (initial burst release) followed by sustained release of 82% till 24 h, where as non enteric coated tablet released more
than half the amount of the drug before reaching the colon area. So, these results conclude the usage of prepared nanoparticles as a
potential drug delivery approach for the treatment of colorectal tumors.