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Development and evaluation of co-polymeric carrier system of Rise | 44071
Journal of Pharmaceutical Care & Health Systems

Journal of Pharmaceutical Care & Health Systems
Open Access

ISSN: 2376-0419

+44 1300 500008

Development and evaluation of co-polymeric carrier system of Riserdronate for the treatment of Osteoporosis


11th World Congress on Pharmaceutical sciences

September 28-29, 2018 | Montreal, Canada

Supriya Verma

Panjab University, India

Posters & Accepted Abstracts: J Pharma Care Health Sys

Abstract :

Aim: The study was intended to develop a copolymer based carrier system of drug Risedronate (RIS) for its effective bone delivery at the target site for the treatment of Osteoporosis (porous bone disease). Summary of The Problem: Risedronate is a FDA-approved third-generation bisphosphonate drug which acts as an antiresorptive agent in the treatment of Osteoporosis. It is a versatile drug molecule, which has been used for the treatment of postmenopausal Osteoporosis, glucocorticoid-induced Osteoporosis, male Osteoporosis and Paget�??s disease. It is available in the market as oral tablet dosage forms but has some challenges like patience in compliance, low drug permeability and is prone to metal chelation, which leads to GIT irritation. Methodology & Theoretical Orientation: The chosen drug (RIS) was entrapped in a copolymer based carrier system, which consists of chitosan, tripolyphosphate (TPP) and eudragit. Chitosan and eudragit copolymer based nanoparticles were prepared by using ionic gelation followed by the coacervation method Observations: The prepared system has been characterized by particles size, PDI, zeta potential and entrapment efficiency, which were found as 272.8 nm, 0.184, 17.9 mV and 77.05 % respectively. FTIR studies proved the user interaction of the drug with the polymeric shells of the system. Moreover, it�??s in vitro release has been carried out in various pH media, i.e., 1.2, 6.8 and 7.4 and was found tremendously better than the conventional system. In ovariectomized rat (in vivo) model, its efficiency and safety were proved 7 times and 10 times of the conventional system respectively. Moreover, the formulation was found stable for the period of six months. Summary & Conclusion: Hence, this is a simple, commercial and easy to scale up method for the preparation of novel drug delivery based nanoparticle system of our choice of drug, i.e., Risedronate

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