Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
ISSN: 2376-0419
H R Kelidari, M Saeedi, J Akbari and K Morteza-Semnani
Posters-Accepted Abstracts: J Pharma Care Health Sys
Spironolactoe (SP) is a poorly water-soluble drug and oral intake as main route of this drug is reported to be associated with low and variable bioavailability and side-effects. SLN and NLCare colloidal carrier systems providing enhance and control drug bioavailability of some drugs. Regarding to the good solubility of SP in lipid materials, SLN and NLC seemed to be an excellent ways to overcome these issues.The SP loaded NLC with Compritol 888 ATO as solid lipid and different Oleic Acid (OA) as liquid lipid content and SLN without OA were prepared by probe ultrasonication method. The average size of the NLC decreased with increase the concentration of OA. All zeta potential of obtained formulations increased dramatically from -13.6 to -35.1 mV by increasing the OA content of nanoparticles. The drug entrapment efficiency with increasing the percentage of OA from 0 to 30 wt% in SLN/NLC increased from 77.1 to 90.6%, respectively. Differential Scanning Calorimeter (DSC) measurements indicated that the presence of OA reduced the melting temperature and melting enthalpy of solid lipid in NLC structure. Dissolution of SP-SLN and SP-NLC3 in 0.1M HCl was 4.8 and 6.5 times faster than raw drugs in 240 min respectively. The release of SP from NLC was higher than SLN due to 30% OA in lipid core. These results indicated that the SP loaded NLC containing 70:30 solid lipid to liquid lipid ratio is a suitable carrier of SP with improved drug EE and drug release properties.