Drug Designing: Open Access
Open Access
ISSN: 2169-0138
+44 1223 790975
ISSN: 2169-0138
+44 1223 790975
Mary Camille Castillo, Ocat, M N; Aquino, J A E; Canto, G P B; Capuno, B M P; Cruz, A T F; Din, G C F; Lucero, D G O; Morales, R V D; Pajarillo, J D L; Pesigan, J M A; Yap, J A C, Yap, P M M Kua, M F
Posters-Accepted Abstracts: Drug Des
Currently, there is a global trend of shifting to the use and research of natural resources for anticancer and antioxidant agents,
because of availability, cost and efficiency. However, in the Philippines, only a few studies were conducted on these sources.
Artocarpus species (Fam. Moraceae), due to the presence of bioactive compounds, have been recently studied for various
pharmacological activities. Prenylated f!avones and f!avonoids are found to contribute to its potential as chemotherapeutic agents.
Also, antioxidant compounds reduce free radicals, which may also lead to the cytotoxicproperties of such compounds. Artocarpus
odoratissimus Blanco (Marang) a member of this family, have been studied for phytochemical contents, antioxidant property,
polyphenol diversity and cytotoxic properties, which show its anticancer potential But, most studies are limited only to the fruit. Also,
there are only few, If not none, which studies on the leaves. Thus, leaves of A. odoratissimus were chosen to be studied
This study aims to characterize the leaves of A. odoratissimus leaves in terms of1is physical properties and bioactivity. Specifically,
li aims to test for the cytotoxic and antioxidant properties, to determine 1is moisture content, total ash content and total extractives
through pharmacopeia/ assays, to obtain the crude a/kalo1d extract via the Stas-Otto procedure, and to characterize the crude a/
kalo1d extract in terms of its solubility and boiling point. The crude extract showed antioxidant activities for both OPPH and CUPRAC
assays. For both assays, results are significantly less than that of the standard (p<O.05}. Aiso, crude extract showed cytotoxic activity
for the brine shrimp lethality assay having LC50 of 1.08 mg/mL. The crude a!ka!OJd mixture obtained was characterized, however,
dJd contain traces of pigment and was not further purified.