Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
ISSN: 2376-0419
Shrikant Y Charde, Prashant P Raut, Pradeep Bishnoi and Hiren Savani
Birla Institute of Technology and Science Pilan-Hyderabad Campus, India
Birla Institute of Technology and Science Pilani, India
Posters & Accepted Abstracts: J Pharma Care Health Sys
For pediatric patients, it is necessary to consider the use of dosage forms which are easy to swallow, disintegrate rapidly in the mouth, offer dose flexibility and which have pleasant taste and appearance. Therefore, study was aimed to design multiunit particulate drug delivery system (Mini-tablets) of amodiaquine hydrochloride (AQ) and artesunate (AS) for treatment of malaria, which can be encapsulated or filled into primary packs such as sachets. Individual minitablets of AS and AQ were manufactured by direct compression and dry granulation technique respectively, using 1.5 mm punches on tablet compression machine (Minipress, Rimek). The designed tablets were evaluated for weight variation, content uniformity and in vitro drug release. Drug release studies were carried out using USP type II apparatus. Dissolution media used during the study was sodium acetate buffer (500 mL, pH 5.5). Paddle rotation was kept at 100 rpm. Further, accelerated stability studies of designed formulations were performed for 6 months. Weight variation, drug content and other physical characteristics of designed tablets were found to be acceptable indicating suitability of technique used for manufacturing tablets. Further, all dissolution study profiles met pharmacopoeial requirements for rapid drug release (i.e. >75% drug released in 45 min). Further, designed formulations were found to be stable at accelerated conditions. It can be concluded that the designed formulations can provide flexibility of dose selection for different age groups. It may also provide fast disintegration which can be exploited through dispersion in water prior to dosing or through oro-dispersion as a mean of administration.