Journal of Developing Drugs
Open Access

Design of lipid-based drug delivery systems to improve the oral Bioavailability of poorly water-soluble drugs

Joint International Conference and Expo on Industrial Pharmacy & 5th Global Pharmacovigilance Summit

April 28-29, 2016 Dubai, UAE

Kazi Mohsin

King Saud University, KSA

Posters & Accepted Abstracts: J Develop Drugs

Abstract :

Optimization of drug solubility and reproducible bioavailability are recognized as one of the major challenges in oral delivery of highly growing poorly soluble drug (PSD, estimated at 40-90%) candidates. Enabling technology, such as lipid-based drug delivery systems, have generated significant attention and gained high priority in recent years for their key roles in the delivery of PSDs. The initial key achievement of these formulation systems is to increase the solubilization of the PSDs by the formation of emulsions, micellar systems or by co-solvency. The current research aimed to demonstrate factors which influence the design of successful lipid formulations in dosage form (including technology conversion) and affect the fate of the PSDs in GI tract after oral administration. The investigational research will also provide additional information regarding current practice of lipid formulations with a particular emphasis on self-emulsifying/microemulsifying drug delivery systems (SEDDS/SMEDDS), the issues and challenges.

Biography :

Email: mkazi@ksu.edu.sa