Clinical & Experimental Cardiology
Open Access

Decreased diastolic wall strain is associated with adverse left ventricular remodeling even in patients with normal left ventricular diastolic function

Joint Conference on 17^th European Heart Disease and Heart Failure Congress and 2^nd International Conference on Cardiovascular Medicine and Cardiac Surgery

March 15-17, 2017 London, UK

Min-Kyung Kang, Chaehoon Han, Sang Muk Hwang, Sung Gu Jung, Han-Kyul Kim, Kwang Jin Chun, Seonghoon Choi, Jung Rae Cho and Namho Lee

Kangnam Sacred Heart Hospital-Hallym University Medical Center, South Korea

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

Aim: The pathophysiology of diastolic dysfunction is complex, but can be simply described as impaired LV myocardial relaxation and/or increased LV stiffness. The objective of this study is to clarify true normal left ventricular (LV) diastolic function and early stage of diastolic dysfunction before relaxation abnormality develops in patients with normal LV diastolic function using simple diastolic wall strain (DWS) in South Korea. Methods: DWS which is a non-invasive, load-independent and reproducible estimator of LV stiffness using 2-dimensional echocardiography use the difference between posterior wall thickness in systole and diastole to approximate LV stiffness. Consecutive 349 patients with normal LV diastolic function by echocardiography were enrolled. According to DWS, patients were divided to two groups: high DWS (>median: 175) vs. low DWS (â�?¤median: 174). Results: Patients with low DWS were more obese and showed higher blood pressure and had more prevalent hypertension and hyperlipidemia. In addition, those with low DWS had higher LV end-systolic volume, LV mass index, E/E and lower ejection fraction and E velocity. Among them, higher LVESV and LVMI were independently associated with low DWS. Conclusion: These data suggests that simple DWS might be helpful in identifying a subgroup of subtle diastolic dysfunction. Our data suggests that early change of diastolic dysfunction might start with abnormal LV geographic changes precede functional changes.

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