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University of KwaZulu-Natal, South Africa
Posters & Accepted Abstracts: J Clin Toxicol
Tetradenia riparia (Hochst.) Codd, Lamiaceae a traditionally used medicinal plant is indigenous to Southern Africa. Studies have shown anti-bacterial and anti-helminthic properties in extracts and compounds from this species. However, cytotoxic assessment of nanoparticles has not been reported. This study investigated the in vitro screening of the nanoparticles for potential cytotoxic activity against the human breast cancer (MCF7) cell line. Data generated were used to plot a dose-response curve of which the concentration of extract required to kill 50% of MCF7 cell population (IC50) was determined to be 5 and 375 �?¼g ml-1 for AgNPs and AuNPs, respectively, after 96 hrs. Gold and silver nanoparticles were also tested for anti-bacterial activity on five pathogenic bacteria. AgNPs were active and showed MIC against E. coli (1.56 �?¼l ml-1), E. faecalis (1.56 �?¼l ml- 1), K. pneumonia (1.56 �?¼l ml-1), P. aeruginosa (12.5 �?¼l ml-1) and S. aureus (50 �?¼l ml-1). MIC using AuNPs was as follows: K. pneumonia (1.56 �?¼l ml-1), E. faecalis (1.56 �?¼l ml-1), E. coli (6.25 �?¼l ml-1), P. aeruginosa (12.5 �?¼l ml-1) and S. aureus (50 �?¼l ml-1). In order to fully extrapolate and reveal the full potential that may be attributed to these nanoparticles, further and more intensive studies must be undertaken.