Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Crosslinked polymeric system for controlled delivery of Loxoprofen: Synthesis, characterization and release kinetics
The Islamia University of Bahawalpur, Pakistan
Posters-Accepted Abstracts: J Pharma Care Health Sys
Non-steroidal anti-inflammatory drugs are known to be associated with serious gastric disorders due to inhibition of Cyclooxygenase (COX) enzyme. Keeping in view this theory, a study was designed to synthesize an intelligent polymeric system and compare the drug release of two different propionic acid derivatives. For the said purpose, 2-hydroxyethylmethacrylate (HEMA) was crosslinked with methacrylic acid through free radical polymerization method, using Ethylene Glycol Dimethacrylate (EGDMA) as crosslinking agent. The non-steroidal anti-inflammatory drug loxoprofen belonging to propionic acid derivatives class was loaded in the crosslinked pH sensitive hydrogel delivery through absorption method. SEM, FTIR, TGA and DSC of synthesized copolymer were performed to evaluate its morphology, crosslinking and thermal stability respectively. Percent drug release of both these drugs was then evaluated at simulated gastric and intestinal medium. It has been concluded that our designed hydrogel system exhibited successful pH sensitive drug delivery because it showed a minimal drug release at gastric simulated pH while highest release at intestinal simulated pH.
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