Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Amna Imtiaz
Shaheed Zulï¬ qar Ali Bhutto Medical University, Pakistan
Scientific Tracks Abstracts: J Clin Exp Cardiolog
Aim of study was to correlate serum ferritin with left ventricular function in beta thalassemia major patients with increased transfusion dependence and to fi nd out whether echocardiography can be used to assess pre-clinical cardiac disease in these patients. 60 patients of beta thalassemia major with increased transfusion dependence were enrolled in this study. Serum ferritin levels of all patients were measured by using indirect Enzyme Linked Immune-Sorbent Assay (ELISA). Echocardiography was performed on all patients by a consultant cardiologist by linking conventional echocardiography with tissue Doppler imaging. On the basis of serum ferritin level, patients were divided in to three groups. Group I consisted of patients having serum ferritin level equal to or less than 2500 ng/ml. A total of 25 patients were placed in this group. GroupII included patients having serum ferritin level between 2500 to 5000 ng/ml. A total of 22 patients were placed in this group. Group III included patients having serum ferritin level more than 5000 ng/ml. Th is group consisted of 13 patients. All patients having serum ferritin below 2500 ng/ml had normal systolic function and only 16% of the patients in this group had diastolic dysfunction as refl ected by abnormal E/A ratio. In group-II, 27% of the patients had systolic dysfunction refl ected by subnormal ejection fraction while 40% of the patients had diastolic dysfunction. In group-III, 62% of the patients had abnormal systolic and diastolic function. Pearson correlation was used to fi nd correlation between serum ferritin and left ventricular function. A strong negative correlation was found which is refl ected by a p value of less than 0.05 which is signifi cant. Chi square test is used to correlate serum ferritin with E/A ratio. P value came out to be less than 0.05 which is signifi cant.
Amna Imtiaz has completed MBBS from University of Health Sciences and MPhil in Hematology from Shaheed Zulï¬ qar Ali Bhutto Medical University. Currently she is working as Lecturer in FMDC. She has published 3 case reports in reputed journals.