Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Dr. Bennett Peter
James Cook University Hospital, United Kingdom
Scientific Tracks Abstracts: Endocrinol Metab Syndr
Background: Hyperparathyroidism is a prevalent disease and parathyroid adenomas are the most common cause. Surgical excision remains the gold standard treatment for parathyroid adenoma. Successful preoperative localization of the parathyroid adenoma could facilitate the decision regarding the extent of surgical exploration. Objectives: The aim of this study is to assess the correlation between the weight and volume of parathyroid adenomas with preoperative biochemical markers like parathyroid hormone (PTH) and ionized calcium in patients with primary hyperparathyroidism caused by single-gland adenoma. Patients and methods: We performed a retrospective review of all patients diagnosed with primary hyperparathyroidism due to solitary parathyroid adenoma in our general surgery department over 4 years. The peak preoperative levels of PTH and ionized calcium were collected. The adenoma volumes were obtained indirectly from the gland dimensions mentioned in the histology report together with the adenoma weight. SPSS software was used to get the correlation coefficient between these values. Results: 99 patients were included in our study. The average age at surgery was 62.65 ± 12 years of age. The correlation coefficient between adenoma volume and weight with the preoperative ionized calcium level was weakly positive; (r= 0.329, p< 0.01) and (r= 0.281, p= 0.019), respectively. While the correlation between adenoma volume and weight with the preoperative PTH level was stronger; (r=0.708, p< 0.01) and (r=0.650, p< 0.01), respectively. Conclusion: We reported a strong positive correlation between the preoperative levels of PTH with the adenoma weight and volume, while the correlation with preoperative calcium level was relatively weak.
Bennett Peter is a trust SHO in General surgery. He is interested in Endocrine and cancer research and keen on improving his knowledge on cancer surgery and treatment. He is interested in research writing and would like to contribute to the ever-expanding field of cancer research.