Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Sonam Agarwal and Renu Bist
Banasthali University, India
Scientific Tracks Abstracts: J Clin Toxicol
Current study emphasizes the toxic effects of dichlorvos on serum in terms of oxidative stress. Meanwhile, a protective action of bacoside A and bromelain was investigated against the biochemical alterations in serum. Experimental design included six groups of mice: Saline was given as a vehicle to the control mice (group I). Mice belonging to groups II, III and IV were administered with dichlorvos (40 mg/kg b.w.), bromelain and bacoside A, respectively. Fifth group received a combination of bromelain and bacoside A. In group VI, bacoside A and bromelain were administered 20 minutes prior to exposure of dichlorvos. Thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) level were used as biochemical test of toxic action for dichlorvos intoxication. Significantly increased TBARS and PCC level in second group suggests that dichlorvos enhances the production of free radicals in serum of mice (p<0.05). Antioxidants treatment significantly decreased the levels of TBARS and PCC (p<0.05). Dichlorvos administration causes a significant reduction in the level of CAT, SOD, GPx and GSH (p<0.05) which was restored significantly by co-administration of bromelain and bacoside A in dichlorvos exposed mice (p<0.05). Treatment of bromelain and bacoside A in combination served as better scavengers of toxicity induced by dichlorvos.
Sonam Agarwal is pursuing PhD in Biotechnology from Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India. She has completed her MSc in Biotechnology from MITS University, Rajasthan, India. Her research work highlights “The role of bacoside A and bromelain against dichlorvos incited toxicity in serum and kidneys of mice”.
Email: sonam.2mits@gmail.com