Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495


Comparative protective potentials of vitamins C and E against nitrocellulose thinner-induced atherogenicity in male and female albino Wistar rats

4th Global Summit on Toxicology

August 24-26, 2015 Philadelphia, USA

Friday EUboh, Saviour Ufot and Uduak O Luke

Scientific Tracks Abstracts: J Clin Toxicol

Abstract :

This study assessed the comparative protective potential of vitamins C (Vit C) and E against nitrocellulose thinner-induced
atherogenicity in male and female albino Wistar rats. Forty eight rats (24 males and 24 females), weighing 180–200 g, were used
in the study. The animals were distributed into four groups, with six rats respectively for each of the male and female groups. The
animals were orally exposed to 30 mg/kg bwt of nitrocellulose thinner (NCT) and respectively treated with Vit C (200.0 mg/kg bwt)
and E (100.0IU/kg bwt) daily for 30 days. At end of the experimental treatments, the animals were sacrificed and plasma collected for
atherogenicity analyses. The atherogenicity was determined from the plasma total cholesterol, triacylglycerol, low density lipoprotein,
high density lipoproteins, and atherogenic indices of the plasma. The atherogenic indices were derived from the plasma lipid ratios,
including TC: HDL, TG: HDL, (TC–HDL)/HDL and Log (TC/HDL). The results showed that the levels of plasma TC, TG, LDL, and
the atherogenic indices recorded for male and female rats exposed to NCT were significantly (p<0.05)higher, while HDL levels were
significantly (p<0.05) lower, compared respectively to the levels recorded for rats in the respective control groups. Also, the increase
in TC, TG, (TC–HDL)/HDL and Log (TC/HDL) and decrease in HDL levels reported for rats exposed to NCT were observed to be
sex-dependent, with females being more vulnerable. These results also showed that concomitant treatment of the respective groups
of rats exposed to NCT with vitamins C and E significantly (p<0.05) protected both the male and female rats against NCT-induced in
atherogenicity. However, the protection potential of vitamin E was observed to be significantly (p<0.05) higher than that of vitamin
C. The results of this study therefore indicated that oral exposure to NCT may cause a higher risk of atherogenic disorders in females
than males; and that vitamin E is more potent than vitamin C in protecting the exposed animals against NCT-induced atherogenicity
in male and female rats.

Biography :

Friday EUboh completed his PhD from University of Calabar, Calabar, Nigeria, and is presently an Associate Professor of Biochemistry, with Toxicology as his area of
research interest. He served as the acting Head of Biochemistry Department in the Department of Biochemistry University of Calabar, Calabar, Nigeria, from 2011 to 2013.
He is a member of Nigerian Society of Biochemistry and Molecular Biology, and Institute of Public Analysts of Nigeria. He has more than 60 papers published in reputable
Journals, and is a reviewer and Editorial Board Member of many Journals of repute. He has also presented many conference papers, locally and internationally.