Comparative genetic mapping of colonic microbiota pre and post di | 6252
Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631

Comparative genetic mapping of colonic microbiota pre and post different surgical procedures: Basic, clinical and pharmacological impacts

Joint International Conference and Expo on Industrial Pharmacy & 5th Global Pharmacovigilance Summit

April 28-29, 2016 Dubai, UAE

Abd Elrazek Mohammad Ali Hussein

Aswan University, Egypt

Posters & Accepted Abstracts: J Develop Drugs

Abstract :

There are several well-established health hazards associated with obesity, e.g., nonalcoholic steatohepatitis (NASH), type 2 diabetes, chronic kidney disease, gastroesophageal reflux disease, gastrointestinal motility disorders, sexual disorders, cerebrovascular stroke, certain cancers, osteoarthritis, depression and others. According to the World Health Organization, worldwide there are about 500 million obese adults and 42 million obese children under the age of five. Childhood obesity became one of the most important public health problems in many countries with special concern to industrial countries. In the United States alone, reports dedicate comorbidities and pre-mature death of children who have severe obesity. The marked increase in the incidence of obesity in the past 30 years is due to several factors, including increased caloric intake (i.e., fast food), changes in the composition of the diet (i.e., flavored meals), a decrease in the levels of physical activity (i.e., sedentary lifestyle), and changes in the gut microbiome suggesting that the same microbiota could exist in pathogenic status (Obesity) and non ��? pathogenic status (after bariatric). The risk of development of complications ��?related-obesity rises with the increase of adiposity, while weight loss can reduce the risk. Bariatric surgery is currently the most effective procedure for the treatment of adulthood obesity. Bariatric surgery is one of the fastest growing operative procedures performed worldwide, with an estimated >340000 operations performed in 2011; the numbers of procedures performed in the United States plateaued at approximately 200000 operations per year. Different bariatric surgical procedures resulting in drastic weight loss and improvement of metabolic and inflammatory status, that may change the Gut microbiota significantly, suggesting that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery. Unfortunately no sufficient data compared different bariatric procedures-related- microbiota changes post bariatric surgeries. Over all clinical and laboratory data will help to distinguish among Bariatrics-related-morbidity and mortality in population.

Biography :