Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

+1-504-608-2390

Comparative effect of Costus afer stem juice and ascorbic acid on kerosene induced haematotoxicity in female albino Wistar rats


4th Global Summit on Toxicology

August 24-26, 2015 Philadelphia, USA

Chinelo Ozojie1, Friday E Uboh1 and Biola Funmilola Egbowon2

Posters-Accepted Abstracts: J Clin Toxicol

Abstract :

Comparative effect of Costus afer stem juice (CASJ) and ascorbic acid (ASC) on kerosene induced haematotoxicity in female albino
Wistar rats was assessed in this study. Twenty eight female albino Wistar rats, weighing 150 – l80 g were used in the study. The
rats were distributed into four groups, with seven rats each. Group 1 served as the control, while group 2 was orally exposed to 2 mg/
kg body weight (bwt) of kerosene for 21 days without being treated with CASJ and ASC. Group 3 was orally exposed to 2mg/kg bwt
of kerosene and treated with 7.5 mg/kg bwt of CASJ, while group 4 was orally exposed to 2 mg/kg bwt of kerosene and treated with
210 mg/kg bwt of ASC daily for 21 days. At the end of the experimental period, the weights of the animals in each group were taken,
the animals sacrificed, and blood samples collected through cardiac puncture for hematological analyses. Hematological parameters
were determined using an auto analyzer. The results of this study showed that exposure to kerosene resulted in a significant (p<0.05)
reduction in body weight and growth rate, RBC, platelets, Hb, PCV, as well as increase in WBC and some differential cells in female
rats. The results of this study indicated that exposure to kerosene induced haematotoxicity in female rats. However, administration of
CASJ and ASC to female rats exposed to kerosene produced a comparable significant (p<0.05) protection against kerosene induced
haematotoxicity in the rats. It may be concluded that CASJ and ASC possess a comparable protection potential against kerosene
induced haematotoxicity in female rats.

Biography :

Chinelo Ozojie had a BSc degree in Biochemistry in 2011 from University of Nigeria, Nsukka, Nigeria. She won a National Essay writing competition in 2004, and a Certificate
of endorsement for outstanding performance by the Institute of Mathematics, Nigeria. She is presently a MSc research student in University of Calabar, Calabar, Nigeria.

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