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Comparative disintegrant properties of Ethiopian potato (Plectran | 43568
Journal of Pharmaceutical Care & Health Systems

Journal of Pharmaceutical Care & Health Systems
Open Access

ISSN: 2376-0419

Comparative disintegrant properties of Ethiopian potato (Plectranthus edulis) starch against Irish potato starch and its optimization in paracetamol tablet formulations


15th Asia-Pacific Pharma Congress

July 18-20, 2018 Melbourne, Australia

Anteneh Assefa, Anteneh Belete and Tsige Gebre-Mariam

Wachemo University, Ethiopia
Addis Ababa University, Ethiopia

Posters & Accepted Abstracts: J Pharma Care Health Sys

Abstract :

Starch is the most commonly used pharmaceutical disintegrant in tablet formulations. The aim of the present study was to assess the disintegrant property of Ethiopian potato (Plectranthus edulis) starch in comparison to Irish potato starch and its optimization in paracetamol tablets formulations prepared by wet granulation method. Tablet properties such as crushing strength, friability, disintegration time and dissolution rate of the tablets were studied for both comparison and optimization studies. The results of comparative study showed that the properties of paracetamol tablets formulated with both starches as disintegrants were affected by their concentration and the Compression Force (CF) and Plectranthus edulis starch exhibited a favorably comparable disintegrant property with Irish potato starch in paracetamol tablet formulations. The study also showed that the CF and disintegrant concentration had significantly affected the response variables (i.e., the crushing strength, friability and disintegration time); hence, these factors were further optimized using central composite statistical design. The optimal conditions were obtained at a CF of 14.40 KN and disintegrant concentration of 5.96%. Under these conditions, the crushing strength, friability and disintegration time were 101.8 KN, 0.3% and 1.34 min, respectively. These values closely matched with the predicted values of the responses at the levels of the factors. Thus, the results of this study indicated that Ethiopian potato (Plectranthus edulis) can be used as an alternative source of starch for its application as a disintegrant in the tablet formulations.

Biography :

E-mail: ante2011@gmail.com

 

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