Combination of Pulsatile and Sustained Effects in Multi-Layer Tab | 40754
Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Combination of Pulsatile and Sustained Effects in Multi-Layer Tablet

Joint Event on 9th World Biomarkers Congress & 20th International Conference on Pharmaceutical Biotechnology

December 07-09, 2017 | Madrid, Spain

Kirolos Raafat, Ragwa M Farid, Ehab R Bendas and Randa Latif

B.Sc.of pharmaceutical sciences, Faculty f Pharmacy & Drug Manufacturing, Pharos Unieristy in Alexandria, Egypt
Assoc. Prof. of pharmaceutics, Faculty of Pharmacy & Drug Manufacturing, Pharos Unieristy in Alexandria, Egypt
Prof. of pharmaceutics,Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Egypt
Assoc. Prof. of pharmaceutics, Faculty of pharmacy, Cairo Univeristy, Egypt

Posters & Accepted Abstracts: J Proteomics Bioinform

Abstract :

The main objective of the present study is to formulate and evaluate a multi-layer pulsatile drug delivery system (MPDDS) for time dependent release. Based on the utilization of different types of polymers in different ratios. The MPDDS was designed to deliver a rapid pulse of drug after a lag time when it is most needed to patients and another quantity of drug delivered over prolonged period for maintenance dose. The model drug, Etodolac, was incorporated in two separate layers. Sodium starch glycolate (SSG) polymer was incorporated in the fast release (FR) layer. Eudragit RSPO and HPMC K15M polymers were blended with the drug in the sustained release (SR) layer. The two layers were compressed into bilayer tablet using a single-punch tablet machine. Three successive polymer layers of OpadryII, HPMC E5/K4M and Surelease were spray coated using a conventional pan coating processes to provide a lag time before drug release. Bilayer tablets were evaluated for pre- and post-compression parameters. Tablet optimization was performed based on in-vitro dissolution behavior. Addition of 6.67% SSG polymer in the FR layer showed 85.02�?±0.50% release in 10 min, which is beneficial in the manufacture of fast and pulsatile release tablets. Polymer mixture of Eudragit RSPO and HPMC K15M (2.5:1) resulted in 72.44�?±0.44% in 12 hours which directly influence the prolongation of drug release. Accession of HPMC K4M to that of E5 (1:80) lengthens the lag time from 2 to 4 hours. Bilayer tablets of etodolac were successfully formulated which achieved a desirable lag time followed by controlled drug release.

Biography :

Kirolos Raafat is researching in the field of modified drug delivery systerms. He started his studies testing different techniques of drug delivery, then currently he is trying the combination of multiple techniques to reach optimized techniques for various drugs. He is currently working in medical healthcare institution and he is working on the enhancement of the clinical pharmacy practice in Egypt. He is targeting to enter the field of long-term treatment modification in his next researches.