Journal of Glycobiology
Open Access

Colorful chemical glycobiology: Simple construction of sweet glycoprobes

Glycobiology World Congress

August 10-12, 2015 Philadelphia, USA

Xiao-Peng He

Posters-Accepted Abstracts: J Glycobiol

Abstract :

Inter cellular glycoligand-receptor recognitions are fundamental biological processes, harnessing numerous dynamic cellular
events. The better understanding of these interactions may aid both the decipherment of the â�?�?glycomicsâ�? and the progress of
targeted theranostics of human diseases. However, owing to the limitations of current biochemical techniques including their
complicated manipulation, long detection time and high detection cost, effective probing of glycoligand-receptor recognitions
remains a key challenge in chemical glycobiology. By combining the modular click chemistry with judicious (supra) molecular
and materials self-assembly tactics, we have developed simple fluorogenic and electro-activegly co-probes for glycobiology.
With these probes, live cancer cells that over express glycoligand receptors can be specifically captured in situ. The glycoprobes
have also proven suitable for monitoring the expression level of pathogenic glycoligand receptors on cancer cells. Meanwhile,
the scope of the glycoprobes has been expended to the imaging of tumor tissues and diagnosis of clinical serum samples.
Tracking of the dynamic endocytosis, translocation and recycling processes of the receptors have been made possible. Our
research provides economic tools facilitating the decipherment of the glycomics as well as unique insights into the early-stage
diagnosis and targeted therapy of human fatal diseases.