Journal of Pharmaceutical Care & Health Systems
Open Access

Cobalt(III) complex with morpholine and 2-acetylpyridine-based ligand: Synthesis, characterization, cytotoxicity, apoptosis induction and molecular modeling study

Pharmaceutical Summit and Expo

October 08-10, 2015 New Delhi, India

Nuruddeen A and Nura S G

Umaru Musa Yar��?adua University, Nigeria

Posters-Accepted Abstracts: J Pharma Care Health Sys

Abstract :

A new N,Nâ�?�?,Nâ�? donor Schiff base ligand from the reaction of 4-(2-aminoethyl)morpholine, with 2-acetylpyridine in presence of sodium azide N3- ion was formed and coordinates with cobalt(II) ion giving rise to coordination complex of cobalt(III). The IR spectra were carried out in 4000â�?�?400 cmâ�?�?1 range. The characteristic IR stretching frequency of the metal complex along with the proposed assignments are summarized in experimental part. The IR spectra of all the complex possess very strong characteristic absorption bands in the region of 1649â�?�?1661cm-1 which is attributed to the C=N stretching vibration of the Schiff base imino functional group. A chemical shift was observed at a region of 2070 and 2043 which is attributed to cobalt to azide metal bond. The spectra for the complex showed Mâ�?�?N bands at a lower wavelength in the range of 477-575 cm-1.The electronic spectra for all the complex was obtained in DMSO solvent and showed absorption band in three distinct regions. The first region ranging from 224 to approximately 280 nm (Ï�?â�?�?Ï�?*) transitions, while the second characteristic wavelength in the region of 281 nm to approximately 409 nm (nâ�?�?Ï�?) transition. The third distinct region ranging from 492 nm to approximately 606 nm is the (LMCT) from the nitrogen atom to the transition metal centre. MTT assay was used to determine the cobalt complexes cytotoxicity against human breast cancer cells MCF-7. Clonogenic assay confirmed the effectiveness of a specific agent on the survival and proliferation of the cells, apoptotic DNA fragmentation assay was done for a type of programmed cell death.

Biography :

Email: nuruddeen001250@gmail.com