Lauve Rachel Tchokouaha Yamthe
Accepted Abstracts: Biochem & Pharmacol
Malaria causes enormous medical, economic, and emotional burden in the world. New and improved treatments for malaria are needed. Plants used in traditional medicines may offer a promising source of antimalarial lead compounds. In this study twenty essential oils were extracted by hydrodistillation from the fruits, leaves, stem bark, seeds, roots and woods of fifteen Camerooninan Annonaceae species (Xylopia aethiopica, Xylopia parviflora, Xylopia quintasii, Xylopia staudtii, Xylopia phloiodora, Monodora brevipes, Monodora myristica, Uvaria angolensis, Uvariodendron calophyllum, Polyalthia suaveolens, Hexalobus crispiflorus, Annona senegalensis, Pachypodanthium confine, Cananga odorata and Enantia chlorantha). Their chemical analysis was conducted using gas chromatography coupled with mass spectrometry. The antioxidant properties were evaluated using standard methods and the antiplasmodial activity against the W2 strain of Plasmodium falciparum was tested in culture. The yields of essential oils extraction ranged from 0.02% to 4.2%. Chemical analysis revealed a predominant terpenic composition, with a majority of sesquiterpenoids in most of the cases (>87%), and various structures with diverse functions. From the evaluation of antioxidant activity, four essential oils from the stem bark of Uvariodendron calophyllum, Pachypodanthium confine, Enantia chlorantha and Xylopia staudtii showed prominent scavinding activity with respective IC50 of 3 mg/ml, 4 mg/ml, 4.7 mg/ml and 4.9 mg/ml. Among the antiplasmodial extracts, two from the stem bark of Xylopia staudtii and Enantia chlorantha were found to be of interest, taking into account their respective radical scavenging activities. The results achieved indicate that essential oils may offer a promising alternative for the development of new antimalarials.