Hala Gabr, Laila A Hegazy, Asmaa A Abdel Aal, Aml S Nasr, Maha H El Sissy, Manal A Badawe and Sahar Hassan
Cairo University, Egypt
National Research Center, Egypt
Misr University for Sciences and Technology, Egypt
Posters & Accepted Abstracts: J Cell Sci Ther
Background: Umbilical cord blood is known as a rich source of hematopoietic stem cells, which makes it a valuable alternative to bone marrow transplantation in hematology and oncology. Aim of Work: The aim of this work was to detect the feasibility of generating insulin producing cells obtained from progenitor cells of cord blood and their success in reversing the hyperglycemia in diabetic rats. Subjects & Methods: The current study was performed on 44 male rats and 6 umbilical cord blood samples collected from 6 normal vaginal deliveries from the obstetric ward of Kasr El Eini Hospitals. Results: The present study confirmed that CB-MSCs are able to differentiate into islets that can secrete insulin in response to glucose in vitro and in vivo. The transplantation of culture expanded, undifferentiated CB-MSCs in experimental diabetic mice reversed hyperglycemia. Conclusions: MSCs offer another non-pancreatic, readily available, non-invasive and inexhaustible source of allogeneic stem cells for cell replacement therapy in diabetes.
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