Journal of Cell Science & Therapy
Open Access

Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair

3^rd World Congress on Cell Science & Stem Cell Research

November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Yiqin Xiong1, Wei Li1, Ching Shang1, Richard M. Chen1, Pei Han1, Jin Yang1, Kryn Stankunas1, Bingruo Wu2, Minggui Pan1, Bin Zhou2, Michael T. Longaker1 and Ching-Pin Chang1

1Stanford University School of Medicine, USA 2Albert Einstein College of Medicine, USA 3Kaiser Permanente Medical Center, USA

Accepted Abstracts: J Cell Sci Ther

Abstract :

Hair follicle stem cells (bulge cells) are essential for hair regeneration and early epidermal repair after wounding. Here we show that Brg1, a key enzyme in the chromatin-remodeling machinery, is dynamically expressed in bulge cells to control tissue regeneration and repair. In mice, sonic hedgehog (Shh) signals Gli to activate Brg1 in bulge cells to begin hair regeneration, whereas Brg1 recruits NF�?ºB to activate Shh in matrix cells to sustain hair growth. Such reciprocal Brg1â�?�?Shh interaction is essential for hair regeneration. Moreover, Brg1 is indispensable for maintaining bulge cell reservoir. Without Brg1, bulge cells are depleted over time, partly through the ectopic expression of a cell cycle inhibitor p27Kip1. Also, bulge Brg1 is activated by skin injury to facilitate early epidermal repair. Our studies demonstrate a molecular circuit that integrates chromatin remodeling (Brg1), transcriptional regulation (NF�?ºB, Gli), and intercellular signaling (Shh) to control bulge stem cells during tissue regeneration.

Biography :

Email:

xiongyiqin@gmail.com