Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
ISSN: 2376-0419
Lamiaa A Shaala and Diaa Youssef
Suez Canal University, Egypt
King Abdulaziz University, KSA
Posters & Accepted Abstracts: J Pharma Care Health Sys
As part of our ongoing efforts to identify biologically active compounds from marine invertebrates, the organic extract of the Red Sea sponge Hemimycale arabica was investigated. Bioassay-directed fractionation of the organic extract of the sponge gave two new hydantoin alkaloids, hemimycalin C and (E)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione in addition to the known compounds hemimycalins A and B and (Z)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione. The structure determinations of the isolated compounds were based on interpretation of the spectral data of the compounds including one- (1H and 13C) and two-dimensional NMR (COSY, HSQC and HMBC) studies as well as HRMS. The new compounds hemimycalin C and (E)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione displayed variable antimicrobial activities against E. coli, S. aureus and C. albicans. Finally, hemimycalin C showed moderate antiproliferative activity against the human cervical carcinoma (HeLa) cell line.
Lamiaa A Shaala has completed her PhD from Alexandria University and Postdoctoral studies from Faculty of Pharmacy at Suez Canal University, Egypt. She has served as a Principal Investigator and Co-Investigator in 16 research projects in the area of drug discovery from marine organisms and marine biotechnology. He has published more than 40 papers in reputed peer-reviewed international journals and has been serving as a Reviewer for several international journals in the field of phytochemistry, marine natural products and biotechnology.
Email: lamiaelnady@yahoo.com