Biologic response of a porcine coronary artery to stent implantation
Clinical & Experimental Cardiology

Clinical & Experimental Cardiology
Open Access

ISSN: 2155-9880

Biologic response of a porcine coronary artery to stent implantation

15th World Cardiac Surgery & Angiology Conference

December 08-09, 2016 Philadelphia, USA

Blaz Mrevlje

University of Ljubljana, Slovenia

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

Introduction: Stent implantation in a coronary artery results in mechanical injury of the vessel wall and involves deendothelization, stretching and tearing of media and in the case of an atherosclerotic plaque also plaque rupture. These processes are followed by the activation of platelets, thrombus formation and inflammation in the vessel wall. Activated chemokines and cytokines activate the proliferation and migration of smooth muscle cells within the media and from media into intima resulting in hypertrophy of the intima and restenosis of the stented segment of the coronary artery. Methods: Three groups of young pigs were included in the study and followed-up with optical coherence tomography 14 days, 1 month and 2 months after angiographically-guided stent implantation. Three types of stents (bare-metal - BMS, drug-eluting - DES and multimode - MMS) were implanted in each individual pig in a randomized fashion. All stents were of 3.0 x 15 mm in size. Results: After 14 days the neointima thickness was 118.77?±54.27?¼m in BMS, 57.15?±12.01?¼m in MMS and 53.04?±9.50?¼m in DES. After 1 month the neointima thickness was 323.02?±174.07?¼m in BMS, 173.46?±60.11?¼m in MMS and 112.08?±26.00?¼m in DES. After 2 months the neointima thickness was 250.25?±213.66?¼m in BMS, 138.86?±110.42?¼m in MMS and 159.55?±53.95?¼m in DES. Conclusion: Biologic response of a porcine coronary artery in terms of neoitnima thickness to stent implantation is as expected according to stent type and the time of follow-up.

Biography :

Email: [email protected]