Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Anwar El-Shahawy
Assiut University, Egypt
Posters & Accepted Abstracts: J Develop Drugs
Paracetamol (acetaminophen) is widely used as an analgesic and antipyretic drug that is commonly available without a prescription. It has been reported as the common cause of drug toxic ingestion. Paracetamol (Acetaminophen) is 4-hydroxyacetanilide and it has worldwide use as analgesic and antipyretic medication that is readily absorbed after administration and has side effects. Paracetamol is metabolized primarily in the liver, into toxic and non-toxic products. Three metabolic pathways are notable, the following figure. The hepatic enzyme metabolizes Paracetamol, in the third pathway forming the toxic product as NAPQI (N-Acetyl-P-benzo-Quinone Imine). The other two pathways yield final products that are safe, and eventually excreted by the kidneys. Recent work has reported that NAPQI is carcinogenic in absence of glutathione due to the repetitive usage of Paracetamol Drug or due to overdose. The calculated electron transfer studies shows that NAPQI has the lowest electron transfer energy with the nucleic acid bases, 0.382 eV by DFT method indicating to the electron transfer from guanine to NABQI inducing cancer effect in the liver. Paracetamol and Paracetamol analogues were studied by histological method. One of the studied analogues can be used safely.
Email: anwarshahawy@gmail.com