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Piyush Bhargava, Suprava Patel, Dnyanesh Amle, O P Tucker, V Jain, R Gahine, P K Khodiar and P K Patra
Pt Jawahar Lal Nehru Memorial Medical College, India
Dr BRAM Hospital Raipur, India
All India Institute of Medical Sciences Raipur, India
Posters & Accepted Abstracts: J Cell Sci Ther
Background: The platelet derived growth factors (PDGFs) & fibrin rich plasma have been reported to accelerate the process of revascularization, formation of granulation tissues & epithelialization at the ulcer site. PDGFs have been proposed to have beneficial therapeutic effects in chronic non healing ulcers (CNHU). The study was designed to assess the role of autologous PDGFs & fibrin rich plasma in management of chronic non healing ulcers. Materials & Methods: A total of 30 CNHUs in 25 patients (after excluding 5 dropouts) were treated by applying locally antibiotic ointment containing autologous PDGFs and fibrin rich plasma. Results: All the 30 ulcers showed signs of improvement upon the topical application of PDGFs enriched antibiotic ointment. 22 out of 30 ulcers achieved complete healing and 8 ulcers were healed partially. The duration and degree of healing process was also affected by various patient related factors. Conclusion: The application of fibrin rich plasma and PDGFs enriched antibiotic ointment was found to be very easy, cost effective and efficient in treating subjects with CNHU.