Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Neelam Balekar and Dinesh Kumar Jain
IPS Academy, India
Posters-Accepted Abstracts: J Pharma Care Health Sys
The latex of Jatropha curcas (Euphorbiaceae) is used as an anti-inflammatory and in various skin diseases such as scabies, eczema, ringworm etc. The present study was aimed to investigate wound healing potential of Jatropha curcas (JC) latex commonly employed by traditional healers and to prove its traditional use through scientific investigation. The wound healing activity of JC latex was determined using antioxidant, antibacterial, fibroblast proliferation with mouse fibroblast L929, excision, incision and dead space wound model in experimental rats. The latex was found to promote fibroblast L929 survivability more than 90%. It exhibited scavenging activity for DPPH with an IC50 value of 20.4 �¼g/mL comparable to butylated hydroxyl toluene (BHT) 12.5 �¼g/mL. The latex was active against Gram positive bacteria, S. aureus and B. subtilis with zone of inhibition 17 mm and 18.5 mm respectively. Topical application of latex (2 and 5%) exhibited high rate of wound contraction, decrease in period of epitheliazation, high tensile strength in excision, incision and dead space wound model in experimental rats. The JC latex provides scientific evidence of wound healing activity due to its antioxidant, antibacterial, and fibroblast as well as topical application of latex promotes wound healing.
Email: neelambalekar@gmail.com