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Munazzah Rafique, Ayesha Nuzhat, Salman Bashir, Dania Al-Jaroudi
Health Information Management. Saudi Arabia
Faculty of Medicine, King Fahad Medical City. Saudi Arabia.
The research center, King Fahad Medical City. Saudi Arabia.
Reproductive Endocrinology and Infertility Department of King Fahad Medical City. Riyadh. Saudi Arabia
Posters & Accepted Abstracts: Endocrinol Metab Syndr
Introduction & Aim: Hypothyroidism affects 2-4% females of reproductive age. Hypothyroidism causes thyroid failure, recurrent miscarriage and failure of In Vitro Fertilization (IVF). Our rationale is to find out the association between hypothyroidism and thyroid antibodies in infertile females and outcomes of ART among them. Method: Retrospective cohort study (IRB number 14-152) was carried out on 196 females who attended Assisted Reproductive Technology Clinic at King Fahad Medical City, Riyadh Saudi Arabia. Age, duration of infertility, cause of infertility, T3, T4, TSH, thyroid antibodies and their fertility outcomes were collected and evaluated by SPSS version 20; New York: IBM Corp. Results: Infertility due to subclinical hypothyroidism was noticed in 27 (13.8%) cases whereas 13 (6.6%) patients had overt hypothyroidism. There is statistically significant association between the presence of thyroid antibodies and hypothyroidism (P=0.000). Thyroid antibodies were positive in 11 (5.6%) cases and negative in 143 (73%) cases. After ART, 46.2% of overt hypothyroid and 22.2% of subclinical could not conceive, and 3.7% of subclinical hypothyroid patients ended up with miscarriage. The probability of infertile hypothyroid females to have elevated TSH levels is significant with (OR 3.916, CI 1.567-9.788, P=0.003). There is 27.67 times risk of having thyroid antibodies in infertile hypothyroid females (OR 27.67, 95% CI 5.56-137.54, P<0.001). Conclusion: Subclinical hypothyroidism and thyroid antibodies are important factors for female infertility that affect the ability to conceive after ART and pregnancy usually culminate with miscarriage.
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