Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Izhar Ben Shlomo and Omry Koren
Bar Ilan University, Israel
Posters-Accepted Abstracts: Endocrinol Metab Syndr
The relation of excess body weight to woman��?s infertility was described as early as 700 years ago. In the modern era Stein & Leventhal described it along with the surgical solution for infertility. The next phase of things was the realization of the role of metabolic factors in the pathogenesis of PCOS, led by the seminal observation on the role of insulin in boosting ovarian androgen production. Current research is on the genetic/genomic level, which attempts to find the culprit to the syndrome in the form of subtle changes in key genes. Throughout all these phases diet remained a first step solution to many cases, although it��?s favorable effect even for lean patients has been revealed only by recent studies. With the recent surge of knowledge on the role of gut microbiome in various human disease states, it was tempting to speculate that it might play a role in the pathogenesis of PCOS. We collect stool samples from PCOS patients of all BMI categories and document their hormonal and clinical profiles. For comparison we obtain stool samples from normal ovulatory women of matched ages and BMI levels and to those of the same PCOS patients after two months of carbohydratepoor diet. Preliminary results indicate a significant difference between gut microbiome of normal ovulatory women as compared to PCOS patients. Two months of diet served to bring the patient��?s microbiome closer to normal. We believe that the composition of gut microbial population plays a central role in the pathogenesis of PCOS.