Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Shiraz Gamal
Al Ne e lain University, Sudan
Posters & Accepted Abstracts: J Proteomics Bioinform
Background: It has been hypothesized that non-intestinal inflammatory diseases such as hepatitis B virus (HBV) and hepatitis C virus (HCV) may trigger immunological gluten intolerance in susceptible people. This hypothesis suggests a possible epidemiological link between these two diseases. Method: ELISA third generation for Hepatitis B surface antigen (HBsAg) was used in 131 blood samples of patients with seropositive and sero negative for celiac disease (CD). Positive and negatives ELISA samples were confirmed using PCR for detection of HBVDNA. Data on various variables were collected from patients CD using a structured questionnaire after taking informed consent. Results: The prevalence of HBs Ag detected in seropositive celiac disease was 9.9% by serology (ELISA) and 8.5% using PCR. PCR detected two samples out of 64 (3.1%) as positive for HBVDNA which were negative by HBs Ag ELISA which indicated occult HBV infection. No statistical significant was difference (P>0.05) among subjects when distribution of HBV was studied on the basis of age and gender. Conclusions: The results herein reported that there was an association between HBV and CD in the Khartoum State, Sudan as evident from the significantly higher prevalence of HBV infection in CD patients compared to CD seronegative patients included in the current study.