Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Andreeva P, Milachich T and Shterev A
Ob/Gyn Hospital ��?Dr Shterev�, Bulgaria
Posters-Accepted Abstracts: Endocrinol Metab Syndr
Patients with polycystic ovaries morphology (Polycystic ovaries-PCO and Polycystic ovary syndrome-PCOS) are very common among the population in infertility centers and women with PCO or PCOS comprised almost one fifth of them, referred to as assisted reproductive technology (ART)-IVF or ICSI. In the same time the control ovarian stimulation in this group is a challenge in terms of a prevention risk of an ovarian hyperstimulation syndrome (OHSS) and the achievement of oocytes and embryos with good quality. However, in the PCO patients very few studies have been published comparing agonist and antagonist protocols. Some of them claimed that in the century of GnRH-agonist it is unreasonable to perform in vitro maturation (IVM) and new gonadotropinreleasing hormone antagonist (anti-GnRH) and agonist GnRH-trigger protocols reliably prevent OHSS. Also metformin treatment before or during ART cycle��?s increases clinical pregnancy rates and decreases the risk of OHSS. There are many modifications such as flexible or inflexible antagonist protocols, mild stimulation or low dose FSH is discussed as a good option. Despite the fact that PCO women experienced excessive ovarian response or may be because of this, in this type of patients are observed several problems concerning fertilization rate (FR), number of immature oocytes and good embryos, implantation rate (IR) and pregnancy rate (PR) with high miscarriage rate. The data, published in the scientific space are controversial. The survey of our database of the women under 37 years, performing ART, represent that the average number of mature oocytes and FR in PCO patient are comparable with those with obstructive type sterility (control group), but cleavage rate is low and achieving of blastocyst is significantly rare among the former. Nevertheless, once we have obtained good quality blastocyst on day five, the PR is similar to the control group. In conclusion, infertile patients with PCO morphology are a problem which has been discussed since the last century but still they raise a lot of unsolved tasks.
Email: andreivp@yahoo.com