Accepted Abstracts: Biochem & Pharmacol
Herbal drugs have been used since ancient times as medicines for the treatment of a range of diseases. According to WHO because of poverty and lack of access to modern medicine as well as self belief, about 65-80% of the world's population living in developing and developed countries depends essentially on plants for primary health care due to easy availability, low price, compatibility with human body, lesser side effects, etc. In traditional medicine, the drugs are used in the form of crude drugs, decoctions, infusions, crude extracts, etc. Further, several plant extracts and phytomolecules, despite having excellent bio-activity in vitro demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or both, resulting poor absorption and poor bioavailability. Hence, delivery of herbal drugs also requires modifications with the object to achieve sustained release, to increase patient compliance, to enhance therapeutic effect, to reduce toxicity, etc. Novel drug delivery system (NDDS) is delivering the herbal drug at predetermined rate at the site of action which minimizes the toxic effects with the increase in bioavailability of the drugs. Incorporation of herbal drugs in the delivery system also aids to increase in solubility, enhanced stability, protection from toxicity, enhanced pharmacological activity, sustained delivery and protection from physical and chemical degradation. Hence, there is great potential in development of NDDS for valuable herbal drugs as it provides efficient and economical drug delivery and it is also adopted at industrial scale. This presentation highlights the current status of the development of novel herbal formulations viz. phytosomes, microspheres, nanoparticles, transferosomes, ethosomes, nanoemulsions, etc. along with their method of preparation, type of active ingredients, route of administration, biological activity and applications of novel formulations.
Arjun Patra has completed his Ph.D. from Birla Institute of Technology, Ranchi, India and presently working as an assistant Professor (Pharmacy) at Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India. He has published more than 50 papers in national & international journals and serving as reviewer of repute. He has around 9 years of teaching and research experience in different reputed institutes in India.