Antiparkinsonian Potential of Cilostazol: Insights Into Nurr-1 an | 59084
Organic Chemistry: Current Research

Organic Chemistry: Current Research
Open Access

ISSN: 2161-0401

+44 7868 792050

Antiparkinsonian Potential of Cilostazol: Insights Into Nurr-1 and Autophagy Roles

Joint Event on Euro Chemistry 2020 & Euro Toxicology 2020 & Advanced Energy Materials 2020

July 15-16, 2020 | Webinar

Shireen A. Hedya

Cairo University, Egypt

Scientific Tracks Abstracts: Organic Chem Curr Res

Abstract :

Cilostazol, a 2-oxo-quinoline derivative, is a selective inhibitor of phosphodiesterase-3 that increases intracellular cAMP levels and activates protein kinase A. Cilostazol exhibited neuroprotection in focal cerebral ischemia in rats, which was attributed to its anti-apoptotic properties. Furthermore, it guarded against hypoperfusion-induced cognitive impairment resulting in protective activity in an animal model of vascular dementia. Interestingly, cilostazol proved to exert favorable effects against Alzheimer’s disease where it enhanced β-amyloid peptide degradation through autophagy modulation in N2a neuronal cells. Together, these findings further support the notion that cilostazol may possess neuroprotective effect and may show beneficial outcome in PD. The aim of this study is to explore the neuroprotective effect of cilostazol in rotenone-induced PD model in rats. Parkinsonian rat pretreated with cilostazol showed minimal neuronal vacuolation and minimal perivascular edema in the midbrain and striatum. Moreover, . Pretreatment of rats with cilostazol improved the motor deficits as verified by a remarkable surge in ambulation and rearing. This could be explained by the fact that cilostazol significantly raised striatal TH content as compared to the rotenone group. . In conclusion, cilostazol could be a promising candidate for PD treatment.

Biography :

Shireen has completed her Master degree at the age of 26 years from faculty of pharmacy Cairo University, Egypt. She is an assistant Lecturer at the pharmacology and toxicology department at faculty of pharmacy Cairo University, Egypt and published two scientific papers at reputable journals.