Drug Designing: Open Access
Open Access

Antibody-proteases as a novel biomarker and a unique target to be applied for biodesign and bioengineering

28^th International Conference on Chemistry & Drug Designing

December 05-06, 2018 | Vancouver, Canada

Sergey Suchkov, Noel Rose, Aleks Gabibov and Harry Schroeder

I.M.Sechenov First Moscow State Medical University, Russia
A.I.Evdokimov Moscow State Medical & Dental University, Russia
European Association for Prediction, Prevention and Personalized Medicine, EU
Johns Hopkins Medical Institutions, USA
Russian Academy of Sciences, Russia
UAB, USA

Posters & Accepted Abstracts: Drug Des

Abstract :

Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs) with a capacity to hydrolyze the antigenic (Ag) substrate. In this sense, proteolytic Abs (Ab-proteases) represent Abs to provide proteolytic effects. Abs against myelin basic protein/MBP with proteolytic activity exhibiting se-quence-specific cleavage of MBP are of great value to monitor demyelination whilst in MS. The activity of Ab-proteases was first registered at the subclinical stages 1-2 years prior to the clinical illness. And the activity of the Abproteases revealed significant correlation with scales of demyelination and the disability of the patients as well. So, the activity of Ab-proteases and its dynamics tested would confirm a high subclinical and predictive (translational) value of the tools as applicable for personalized monitoring protocols. Of tremendous value are Ab-proteases directly affecting remodeling of tissues with multilevel architectonics (for instance, myelin). By changing sequence specificity one may reach reduction of a density of the negative proteolytic effects within the myelin sheath and thus minimizing scales of demyelination. Ab-proteases can be programmed and re-programmed to suit the needs of the body metabolism or could be designed for the development of new catalysts with no natural counterparts. Further studies are needed to secure artificial or edited Ab-proteases as translational tools of the newest generation to diagnose, to monitor, to control and to treat and rehabilitate MS patients at clinical stages and to prevent the disorder at subclinical stages in persons-at-risks.

Biography :

E-mail: ssuchkov57@gmail.com