Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
ISSN: 2167-0501
Leila Maria Leal Parente, Leonice Manrique Faustino Tresvenzol, Jose Realino de Paula, Elizama Rodrigue Alves, Beatriz Abdallah Chaibub and Maria Teresa Freitas Bara
Accepted Abstracts: Biochem & Pharmacol
In this work, angiogenic activity of Curcuma longa L. (Zingiberacea) oil extract was evaluated, considering traditional use and medicinal properties associated to this plant. Oil extract was obtained with the Curcuma longa originated from Brazil, state of Goi�s, in September 2012, and through layer chromatography, we identified presence of curcumin. Experimental protocol with animals used in this study was approved by the Research Ethics Committee of the Federal University of Goias. Chorioallantoic membrane (CAM) of 30 embryonated eggs were used to evaluate angiogenic activity. Effect of vascular proliferation was evaluated by morphometric analysis to fresh fragment and blood vessels count of CAM to planimetry by point counting. Results were submitted to statistical treatment by use of GraphPad InStat software (Version 3.05 for Windows). From the Kolmogorov- Smirnov test for normality, the CAM data were evaluated by Unpaired or Mann-Whithey test. Angiogenic activity to extract oil was evidenced both by morphometry (p<0.0001) as increase in the number of blood vessels (p=0.01). From results obtained in this work, we can conclude that the Curcuma longa presented positive effect on angiogenesis characterized by the induction of neovascularization. This effect can demonstrate use in further studies on process of wound healing, since angiogenesis is a step in the repair process
Veterinary Medicine, Federal University of Vi�osa (1990). She specializes in Science, Federal University of Goi�s (UFG) (2000). She obtained master's degree in Biology, concentration area-Animal Physiology by UFG (2004) and Ph.D. in Animal Science, concentration area-Pathology and Surgery by UFG (2008). She has experience in veterinary medicine, with emphasis on veterinary clinic and complementary veterinary medicine. She specializes in Herbal Medicine, Faculty of Pharmacy, UFG (2010). It is scholarship Postdoctoral of Scientific and Technological Development Fund (2010-2013), which conducts research to evaluate healing wound activity and ticks control with medicinal plants. It is scholarship postdoctoral of Coordination of Improvement of Higher Education Personnel Fund (CAPES) (2013-2015), which conducts research to test effect of herbal shampoo for dogs. She is related to OMICS Groups and Brazilian Animal Science.