Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Qiong Qiu, Li Ya Ng, Jing-Ting Mai, Ying Yang, Yong Xie, Yang-Xin Chen and Jing-Feng Wang
Sun Yat-sen University, China
Key Laboratory of Cardiac Electrophysiology and Arrhythmia, China
Posters & Accepted Abstracts: J Clin Exp Cardiolog
Multisite biventricular pacing (MSP) has been developed to improve cardiac resynchronization therapy, but its utility was not sure. Accordingly, we systematically evaluated the acute eff ects of MSP on dyssynchrony and heart function in canines with heart failure. Aft er 3 weeksâ�?�? rapid right ventricular pacing (RVP), 7 canines were implanted with 4 left ventricular(LV) leads on anterior, lateral, posterior and apical wall, and followed by MSP and conventional biventricular pacing(BVP). Hemodynamic, ECG and echocardiographic indexes were measured. Intra-ventricular mechanical dyssynchrony were quantifi ed by Yu-index (longitudinal direction) from tissue Doppler imaging, and the standard deviation of time to peak radial strains (SD�?µ, radial direction) from speckle tracking imaging. As a result, compared with BVP, MSP reduced QRS width, Yu-index and SD�?µ (all P<0.05). Meanwhile, only LV end-diastolic pressure (LVEDP) decreased signifi cantly in MSP when comparing to BVP (P<0.05). Between the best and worst MSP (according to dP/dtmax), signifi cant diff erences were found in LVEDP, dP/dtmax, QRS width, YU-index and SD�?µ (all P<0.05). Acute MSP possessed better synchronous contraction and diastolic heart function than BVP, and the LV pacing sites is an important determinant.