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Aminu Muhammad and Hasnah Mohd Sirat
Bayero University Kano, Nigeria
Universiti Teknologi Malaysia, Malaysia
Posters & Accepted Abstracts: J Proteomics Bioinform
This study has tested the in vitro anti-acetylcholinesterase activity of compounds isolated from the stem bark of Bauhinia rufescens by employing TLC bioautographic and Ellmanâ�?�?s spectrophotometric methods. Among the compounds oxepin (IC50, 516.63 �?¼M), seqouyitol (IC50, 463.77 �?¼M) and �?±-amyrin acetate (IC50, 832.80 �?¼M) which exhibited a significant acetylcholinesterase inhibitory activity in comparison with a positive control, the galantamine hydrobromide (IC50, 2.92 �?¼M). The phytochemicals isolated from the stem bark of B. rufescens had demonstrated a potent anti-cholinesterase inhibition.